DPH Announces End to Measles Outbreak in Upstate at 997 Cases

The South Carolina Department of Public Health (DPH) declared a formal end to the measles outbreak in the Upstate that totaled 997 cases from October 2025 through March of this year.

Health officials said the last confirmed case was reported March 15, and a period of 42 days of no new cases is required to declare the end of a measles outbreak. This number is double the number of days for an incubation period (21 days) and is a clear indicator of a broken transmission chain.

The officials also said vaccination continues to be the best way to prevent measles and future outbreaks. Vaccines are available at many primary care provider offices and pharmacies, as well as DPH Health Departments.

In a statement, Interim Agency Director Dr. Edward Simmer said: “Today, as we declare an end to the Upstate measles outbreak, the largest in the United States in more than 35 years, I wish to humbly and profoundly thank the many South Carolinians whose hard work prevented this outbreak from becoming far larger and more serious than it could have become. I am very thankful for their efforts and support during this challenging time.”